Cardiovascular risk factors and dementia

Cardiovascular risk factors also associated with dementia

The risk factors – smoking, serum cholesterol, blood pressure, lung function and the presence of CVD at baseline – were associated with death from dementia. The risk was 58% greater for heavy compared to non-smokers, 55% greater for hypertensives compared to those with normal blood pressure, 73% greater for those with a high level of serum cholesterol, 46% lower for those with a high compared  to a low lung function and 94% greater for those with a history of CVD at baseline compared to those with no such history. Men with a combination of two of the risk factors had a 2 times greater risk of death from dementia. These results suggest that that cardiovascular risk factors measured in midlife predict the risk of death with dementia.

Cardiovascular risk factors measured in the Seven Countries Study

Cardiovascular risk factors were measured at baseline and 160 out of 10,211 middle-aged men died from dementia during 40 years of follow-up. The results of the SCS suggest that cardiovascular risk factors affect the neurodegenerative process leading to dementia.

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