Healthy aging

Focusing on the elderly from 1984 onwards

Because the cohorts of the Seven Countries Study and the general population were growing older, a decision was made to follow the increasingly older cohorts to study aging in the elderly – and its associations with various factors including diet and lifestyle.

The small cohort of survivors in Zutphen was supplemented with a new community sample of the same age. Thus, new studies were started in the elderly with a focus not only on the determinants of cardiovascular disease but also on healthy aging.

The FINE study and the HALE project assessed what healthy aging actually entailed and studied, in particular, the influence of diet, lifestyle and risk factors on different aspects of health.

Physical activity, APOE4 genotype and cognitive decline

Physical activity reduces the risk of stroke and may subsequently diminish the risk of cognitive decline, but changing the level of activity is more influential than maintaining it.

Physical activity, APOE4 genotype and cognitive decline

Hand-grip strength and disability

Hand-grip strength related to lower disability Hand-grip strength at baseline was inversely related to 4-year disability in rural elderly men in Italy. Of the men with [...]

Hand-grip strength and disability

Optimism and cardiovascular disease

High optimism low CVD mortality Optimism was a relatively stable trait over 15 years in the Zutphen Elderly Study. Elderly men with a high level of [...]

Optimism and cardiovascular disease

Depressive symptoms and cardiovascular disease

Depressive symptoms related to CVD mortality Elderly men from the FINE study cohorts of Finland, the Netherlands and Italy who manifested a number of depressive symptoms [...]

Depressive symptoms and cardiovascular disease

Loneliness and mortality in the Zutphen cohort of elderly men

Loneliness is prevalent in the elderly and included emotional and social loneliness. Information about loneliness was collected four times between 1985 and 2000. At baseline, 39% [...]

Loneliness and mortality in the Zutphen cohort of elderly men

Chronic diseases and all-cause mortality

The relations of different chronic diseases with all-cause mortality was studied from middle-age onwards in the Seven Countries Study and in old age in the FINE Study.

Chronic diseases and all-cause mortality

Telomeres and all-cause mortality

Longer telomeres at baseline did not predict all-cause mortality, even though telomere shortening is a marker of ageing that might be related to oxidative stress.

Telomeres and all-cause mortality