Disease outcomes

A selection of study findings on disease outcomes in the Seven Countries Study.

Physical activity, APOE4 genotype and cognitive decline

Physical activity reduces the risk of stroke and may subsequently diminish the risk of cognitive decline, but changing the level of activity is more influential than maintaining it.

Physical activity, APOE4 genotype and cognitive decline

Hand-grip strength and disability

Hand-grip strength related to lower disability Hand-grip strength at baseline was inversely related to 4-year disability in rural elderly men in Italy. Of the men with [...]

Hand-grip strength and disability

Chlamydia pneumonia and coronary heart disease

Chronic chlamydia infection related to 3-fold higher CHD risk In the Zutphen Elderly Study a high level of antibodies to C. pneumonia was associated with an almost [...]

Chlamydia pneumonia and coronary heart disease

Long QT interval and coronary heart disease

Long QT interval related to high risk of CHD mortality A long QT interval in the resting ECG was associated with a 4-fold 15-year CHD mortality [...]

Long QT interval and coronary heart disease

White Blood Cell count and coronary heart disease

High White Blood Cell count, high CHD mortality A high White Blood Cell (WBC) count is associated with a higher CHD mortality in the Zutphen Elderly [...]

White Blood Cell count and coronary heart disease

Body mass index and all-cause mortality

Underweight and overweight related to all-cause mortality In the European cohorts of the SCS middle-aged men with a body mass index (BMI) <18.5 kg/m2 had a 2-fold [...]

Body mass index and all-cause mortality

Four lifestyle factors and all-cause mortality

A healthful diet and lifestyle are related to a low all-cause mortality risk A Mediterranean style diet, a high level of physical activity, non-smoking and moderate [...]

Four lifestyle factors and all-cause mortality

Global coronary risk in northern and southern Europe

Large differences in global CHD risk within Europe A re-analysis of the 10-year follow-up data of the SCS published in 2000 showed large differences between northern and southern [...]

Global coronary risk in northern and southern Europe

From individual risk factors to global cardiovascular risk

Individual risk factors and CHD prevention in the past In the 1960s and 70s, the Seven Countries Study and many other studies identified serum cholesterol, systolic blood [...]

From individual risk factors to global cardiovascular risk

Major risk factors and cardiovascular disease

High blood pressure and smoking were risk factors for three major CVDs while serum cholesterol predicted only CHD Blood pressure and cigarette smoking predicted overall cardiovascular disease [...]

Major risk factors and cardiovascular disease