Genotypical risk factors, stroke and cognitive decline

Genotype apolipoprotein E4 (APOE4) associated with cognitive decline

The Zutphen Elderly Study showed that the risk of cognitive decline over three years was 3 times greater among the carriers of an isoform (certain variety of the genotype apolipoprotein E) called APOE4, compared to that of non-carriers.

Synergistic effect of genotype APOE4 and stroke on cognitive decline

Carriers of APOE4 without stroke had a 3 times greater risk of cognitive decline; non-carriers with stroke had a 5 times greater decline and those with both risk factors had a 17 times greater risk of decline.

Genotypes explained

Cognitive decline is a potential risk factor for reduced cognitive functioning. The genetic heterogeneity of apolipoprotein E may be involved in the etiology of familial Alzheimer’s disease. The apolipoprotein E polymorphism affects serum lipoprotein levels and the APOE4 isoform is increased in Alzheimer’s disease.

About the Zutphen Elderly Study

The Zutphen Elderly Study is an extension of the original Zutphen Study with a sample of the same age where detailed information on the diet of all the participants was collected four times between 1985 and 2000.  Read more about the Zutphen (Elderly) Study.

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