Genotypical risk factors, stroke and cognitive decline

Genotype apolipoprotein E4 (APOE4) associated with cognitive decline

The Zutphen Elderly Study showed that the risk of cognitive decline over three years was 3 times greater among the carriers of an isoform (certain variety of the genotype apolipoprotein E) called APOE4, compared to that of non-carriers.

Synergistic effect of genotype APOE4 and stroke on cognitive decline

APOE4 and stroke

Carriers of APOE4 without stroke had a 3 times greater risk of cognitive decline; non-carriers with stroke had a 5 times greater decline and those with both risk factors had a 17 times greater risk of decline.

Genotypes explained

Cognitive decline is a potential risk factor for reduced cognitive functioning. The genetic heterogeneity of apolipoprotein E may be involved in the etiology of familial Alzheimer disease. The apolipoprotein E polymorphism affects serum lipoprotein levels and the APOE4 isoform is increased in Alzheimer disease.


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Studies in the elderly

The Zutphen Elderly, HALE and FINE studies researched the indicators of healthy ageing.

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