Glucose intolerance and diabetes associated with the risk of fatal CHD
Dutch men aged 50-69 with glucose intolerance at entry, followed for 15 years, had a 2-fold greater risk of fatal CHD compared to men with normal glucose tolerance. A similar result was obtained for men who entered the study with clinical diabetes.
In 1970 in the Zutphen Study, a glucose tolerance test was carried out with an oral load of 50 g glucose. Blood samples were taken after 30, 60, 120 and 150 minutes. The area under the curve of glucose values was calculated and ‘glucose intolerance’ was based on values above the median.