Long QT interval related to high risk of CHD mortality

A long QT interval in the resting ECG was associated with a 4-fold 15-year CHD mortality risk in middle-aged men and a 3-fold 5-year risk in the elderly men of Zutphen. These associations could not be attributed to prevalent heart disease and were independent of other cardiovascular risk factors.

Interpretation

Middle-aged men in the general population having long QT syndrome were at greater risk of fatal CHD. Though few men in Zutphen had a clearly abnormal QT interval, risk increased gradually within the range of usual or normal values in the population.

About the Zutphen Elderly Study

The Zutphen Elderly Study is an extension of the original Zutphen Study with a sample of the same age where detailed information on the diet of all the participants was collected four times between 1985 and 2000.  Read more about the Zutphen (Elderly) Study.